Mitochondria play a pivotal role in chemical toxicity and many diseases, including hereditary mitochondrial disorders, neurodegenerative disorders, cancer, and diseases caused by misregulated inflammatory processes. The aim of the FRIAS Junior Researcher Conference, organized by Verónica I. Dumit (Freiburg), Florian Steinberg (Freiburg), Ralf Zerbes (Freiburg), Ralf Braun (Bayreuth) and Denis Gris (Sherbrooke, Canada) is to bring local, national, and international junior and established senior researchers together working on the molecular aspects of chemical toxicity and different diseases. The symposium intends to outline common and distinct roles of mitochondria upon these pathophysiological conditions. Researchers using different model systems, and applying various experimental approaches are highly welcome to attend and contribute to this symposium! The organizers trust in a fruitful scientific communication enabling the transfer of knowledge and the appointment of exciting new collaborations.